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Laura Ochoa Callejero

Laura Ochoa Callejero

Researcher in the Angiogenesis Unit

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Address: C/ Piqueras 98 (Edificio CIBIR) 26006 Logroño (La Rioja)
Área: Angiogenesis Unit
Teléphone: +34 941 278 770 (Ext.: 84868)



CURRICULUM

Dr. Ochoa obtained her B.S. degree in Biology at the University of Navarra (1998-2001) and received her Ph.D. in Hepatology and Gene Therapy from the University of Navarra in 2007. During her thesis she worked on the development of new vaccination strategies against hepatitis B infection and in the study of novel immune evasion mechanisms of HBV. Dr. Ochoa carried out postdoctoral research at the University of Cologne (Germany) under the supervision of Dr. Manolis Pasparakis, where she studied the role of NF-kB signaling pathway in hepatocarcinogenesis within the European project, “Functional genomics approaches in animal models to study human immunological disease”. In February 2009, she joined the Oncology Area at the Center for Biomedical Research of La Rioja (CIBIR). Dr. Ochoa primary research interests include the design, characterization, and application of anti-tumoral therapies based on new anti-angiogenic strategies.

Publications

  • Neuroprotection and behavior regulation by adrenomedullin and PAMP as shown by conditional knockout models. L Ochoa-Callejero, J García-Sanmartín, IM. Larráyoz and A Martínez. Review Current Hyperten. In Press.
  • Adrenomedullin and Related Peptides. J García-Sanmartín, IM. Larráyoz, L Ochoa-Callejero, A Martínez. Handbook of Biologically Active Peptides. In Press.
  • Ehlken H, Kondylis V, Heinrichsdorff J, Ochoa-Callejero L, Roskams T, Pasparakis M. Hepatocyte IKK2 Protects Mdr2 Mice from Chronic Liver Failure. PLoS One 2011;6(10):e25942. Epub 2011 Oct 14
  • A Palazón, A Rouzaut, S Hervás-Stubbs, J Dinchuk, A Teijeira, J Dubrot, I Martínez-Forero, A Morales-Kastresana1, JL Pérez-Gracia, M.C Ochoa, L Ochoa-Callejero, A Martínez, A Luque, M Jure-Kunkel, I Melero. Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes. Cancer Res. 2011 Feb 1;71(3):801-11. Epub 2011 Jan 25
  • L. Ochoa-Callejeroa, I. Otano, A. Vales, C. Olagüe, P. Sarobe, J.J. Lasarte, J. Prieto, S. Menne, G. González-Aseguinolaza. Identification of CD4+ and CD8+ T cell epitopes of woodchuck hepatitis virus core and surface antigens in BALB/c mice. Vaccine. 2010 May 28.
  • Rodrigo-Garzón M, Berraondo P, Ochoa L, Zulueta JJ, González-Aseguinolaza G. Antitumoral efficacy of DNA nanoparticles in murine models of lung cancer and pulmonary metastasis. Cancer Gene Ther. 2009 Jul 3.
  • Crettaz J, Berraondo P, Otano I, Pañeda A, Ochoa L, Vales A, Olagüe C, Prieto J, Menne S, González-Aseguinolaza G. Treatment of chronic viral hepatitis in woodchucks by prolonged intrahepatic expression of interleukin-12. J Virol. 2009 Mar;83(6):2663-74.
  • Berraondo P, Crettaz J, Ochoa L, Vales A, Ruiz J, Prieto J, Martinez-Ansó E, González-Aseguinolaza G. Production of Recombinant Woodchuck IFNalpha and Development of Monoclonal Antibodies. J Interferon Cytokine Res. 2008 Nov 17.
  • Gómez C, Nájera J, Domingo-Gil E, Ochoa L, González-Aseguinolaza G, Esteban M. Distribution and innate immune responses triggered by attenuated MVA and NYVAC poxvirus strains. J. Gen. Virol 2007 Sep;88(Pt 9):2473-8.
  • Ochoa L, Berraondo P, Crettaz J, Olagüe C, Vales A, Ruiz J, Prieto J, Tennant BC , Menne S, González-Aseguinolaza G. Dendritic cells generated from woodchuck peripheral blood mononuclear cells and transduced with human rAd5 are able to induce antigen specific cellular immune responses. J. Med. Virol. 79:522-529, 2007.
  • Paneda A, Crettaz J, Ochoa L, Otano I, Aldabe R, González-Aseguinolaza G. Gene therapy for viral hepatitis. Expert Opinion on Biological Therapy (EOBT) Review. 2006 Dec;6(12): 1263-1278.
  • Crettaz J, Berraondo P, Mauleón I, Ochoa L, Shankar V, Zabala M, Barajas M, Kochanek S, Quian C, Prieto J, Hernández-Alcoceba R, González-Aseguinolaza G. Improvement liver gene transfer with first and third generation adenoviral vectors. Hepatology. 2006 Sep;44(3):623-32.
  • Berraondo P, Crettaz J, Ochoa L, Pañeda A, Prieto J, Troconiz IF, González-Aseguinolaza G. Intrahepatic injection of rAAV serotype 2 overcomes gender-related differences on liver transduction. Hum Gene Ther. 2006 Jun;17(6):601-10.
  • Berraondo P, Ochoa L, Crettaz J, Rotellar F, Vales A, Martínez-Ansó E, Zaratiegui M, Ruiz J, González-Aseguinolaza G, Prieto J. IFNα gene therapy for woodchuck hepatitis with adeno-associated virus: differences in duration of gene expression and antiviral activity using intraportal or intramuscular routes. Mol Ther. 2005 Jul;12(1):68-76.
  • Garzón MR, Berraondo P, Crettaz J, Ochoa L, Vera M, Lasarte JJ, Vales A, Van Rooijen N, Ruiz J, Prieto J, Zulueta J, González-Aseguinolaza G. Induction of gp120-specific protective immune responses by genetic vaccination with linear polyethylenimine-plasmid complex. Vaccine. 2005 Feb 3;23(11):1384-92.
  • González-Aseguinolaza G, Schmiegh J, Berraondo P, Ochoa L and Tsuji M. The involvement of CD1d-restricted NKT cells in infectious processes. Inmunología. 2002 Mar; 21 (3):145-155.

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