Angiogenesis

Team

  • Principal Investigator: Alfredo Martinez Ramirez
  • Postdoctoral researcher: Laura Ochoa Callejero
  • Postdoctoral researcher: Josune Garcia Sanmartin
  • Postdoctoral researcher: Miriam Bobadilla Muñoz
  • Postdoctoral researcher: María Pilar Martínez Moral
  • Laboratory technician: Judit Narro Iniguez
  • Master students: 1
  • Predoctoral Student: Pablo Garrido Rodríguez
  • Other PhD students:
    • Marcos Vilarino Camean: CIBIR.
    • Alfonso Martin Carnicero (Hospital San Pedro)
    • Maria Diaz de Cerio (CIBIR)
    • Francisco Julián Villaverde (Hospital San Pedro)

Research

The group's study is focused on the production (or inhibition) of new blood vessels in different high-impact diseases where the growth (or inhibition) of new vessels may be an important therapeutic target for the development of new treatments that improve the life of patients and their caregivers.

In general terms this research aims to:

  1. Better understand the mechanisms underlying the appearance and development of these diseases.
  2. Design new therapeutic strategies.

Among the diseases studied, the most important are cancer (melanoma, colorectal cancer, breast cancer, etc.), stroke and the formation of sores and wounds. The group also studies other related phenomena, such as Alzheimer's disease or osteoporosis.

All the diseases studied by the group have a great incidence in the Riojan population.

General objectives:

  1. Design projects to know the mechanisms involved in the onset of the disease.
  2. Search for molecules with therapeutic potential.
  3. Protection of candidate molecules (patent)
  4. Exploitation and preclinical development.
  5. Completion of the clinical trial for stroke with a periodic acceleration platform

Other lines:

  • Colorectal cancer
  • Alzheimer's and Aging
  • Therapeutic hypothermia against traumatic eye damage
  • Validation and development of a patent in the prevention / treatment of-Osteoporosis
  • Validation of a detection system in breast cancer

Principal Researcher

Alfredo Martínez

Phone: +34 941 278 855

Biosketch

Alfredo Martínez completed undergraduate studies in Biology and obtained a PhD in Cell Biology (University of Navarra, Pamplona, 1991). He performed post-doctoral training in Vancouver (University of British Columbia), Dublin (Trinity College), and London (Hammersmith Hospital). He spent 11 years at the National Cancer Institute (NIH, Bethesda, MD, USA) as a Visiting/Staff Scientist under the supervision of Dr Frank Cuttitta. He returned to Spain in 2004 to lead a research team at the Cajal Institute (Spanish Council for Scientific Research, CSIC) in Madrid. In 2008 he won the call for the position of Group Leader at the Oncology Area of the CIBIR. His main line of work centers on the development of new pro- and anti-angiogenic therapies in the fight against cancer, Alzheimer´s disease, and other clinically relevant diseases. His studies usually involve genetically engineered mice as well as cutting-edge techniques at the molecular and cellular level. The angiogenesis laboratory believes in translational (from bench to bedside) research and is leading several clinical trials based on basic observations made by the group.

Dr Martínez´s curriculum contains more than 190 publications in specialized international journals and he has been the principal investigator of numerous national and international research grants.

Publications

 

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Work Team

Laura Ochoa Callejero

Laura Ochoa Callejero

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 278 855, (Ext.: 84868)

Biosketch

Dr. Ochoa obtained her B.S. degree in Biology at the University of Navarra. She received her Ph.D. in Hepatology and Gene Therapy (CIMA). During her thesis, she was a visiting fellow at Cornell University (Gastrointestinal Unit, Department of Clinical Sciences, School of Veterinary Medicine). Dr. Ochoa carried out postdoctoral training at the University of Cologne (Institute for Genetics). In 2009, she joined the Oncology Area at the Center for Biomedical Research of La Rioja (CIBIR). Dr. Ochoa’s research has been focused on angiogenesis, immunology, viral hepatitis and hepatocarcinoma, including the design, characterization, and application of novel anti-tumoral therapies. In 2013, Dr. Ochoa was awarded with a prestigious fellowship from the UICC for a short time stay at the University of Western Australia (Dept of Biochemistry and Molecular Biology). She has been the Principal Investigator of La Rioja team in a trans-pyreneean Project, and of a regional project aimed to study the impact of CCR5 on macrophages and liver progenitor cells in the progression of HCC.

Additionally, Dr. Ochoa counts with a broad experience in experimental animal manipulation (Felasa, Category C). Moreover, she obtained the Aptitude Certificate as well as the B2 English language certification. She received the Assistant Teacher Doctor accreditation by The National Agency for Quality Assessment and Accreditation of Spain (ANECA). She belongs to the Hospital San Pedro Teaching Unit as a Research collaborator. From 2013 is an assistant teacher of Anatomy, School of Nursing at the University of La Rioja. Besides, during her career has mentored master as well as summer students.

Dr. Ochoa has published more than 30 papers related to cancer research in high impact journals, more than 40 communications at international and national conferences and also has been involved in several projects funded by private as well as public entities. Currently, Dr. Ochoa participates as an external expert reviewing scientific articles (Sci Reports) as well as National and European research projects. She has also participated in 1 international patent. Besides, she is an EACR Ambassador and member of the ASEICA and AEEH.

eacr

Publications

 

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Josune García

Josune García

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 278 770 (Ext.:84868)

Biosketch

Josune García studied Veterinary Medicine at the University of Zaragoza, where she graduated in 1999. After graduation, she worked for 6 months as the responsible veterinarian in a sheep farm of "Rasa Aragonesa" (Gabinete Tecnico Veterinario, Zaragoza, Spain) allowing her to gaining considerable expertise in sheep livestock.

From 2000 to 2003 she received several grants to study facial eczema disease in a sheep population from Northern Spain working for Neiker Tecnalia (Spain). Then, she got a Predoctoral Scholarship from INIA (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria), which was supervised by Dr Ana Hurtado Esgueva and Dr Ana Garcia Perez, also from Neiker Tecnalia. Her PhD research focused on the molecular identification of piroplasm species in the Ixodida populations, livestock, and wildlife of the Basque Country, providing her with an excellent background in multiple biological disciplines including molecular biology, microbiology, biochemistry, and genetics. From 2007 to 2008 she performed postdoctoral training in the laboratory for the diagnosis of Avian Influenza from the Basque Government and in the epidemiological study of the bluetongue disease in the Basque Country (Neiker Tecnalia).

In 2008 she joined Dr. Alfredo Martinez´s team in the Oncology Area of the CIBIR. Her work is focused now on the study of new anti-angiogenic therapies in the fight against cancer.

During her undergraduate and graduate studies, she received several academic awards such as a Socrates-Erasmus scholarship, Training fellowships for young researchers and technologists from the Basque Government, Scholarship for conducting Doctoral thesis in the enterprise from the Industry department of Basque Government, Predoctoral Scholarship from INIA, and Extraordinary PhD award.

Results from her research have been published in high impact journals.

Publications

 

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Marcos Vilariño Cameán

Marcos Vilariño Cameán

Phone: +34 941 278 855

Biosketch

Marcos Vilariño Cameán obtained his bachelor's degree in Biology, with the Fundamental and Sanitary specialty, by the University of Navarra in the year 2000, and his bachelor's degree in Biochemistry from the University of Navarra in 2001. He later graduated in Food Technology through the University Master's Degree in Food Biotechnology at the University of Oviedo in 2002.

He continues his apprenticeship in food subjects through the completion of the Master in Innovation, Production Technology and Aquaculture Management (MITGA) of the IGAFA in 2004. He has a postgraduate degree in "Specialization in Promotion and Management of International R+D+I "at the Technical University of Madrid (UPM) in 2014 as part of his continuing education.

Currently, he develops his professional career combining the tasks of Biosecurity and Quality Manager and of the EU and International R&D and Innovation Project Manager at the La Rioja Biomedical Research Center (CIBIR) belonging to the Rioja Health Foundation in Logroño. Is in agreement with the accomplishment of his doctoral thesis directed by Dr. Alfredo Martínez in a subject related to the anticancer properties of the mushrooms in the University of La Rioja in the Doctorate Program of Biomedical and Biotecnological Sciences.

During his career he continued to train in Quality and PRL through the realization of various training courses and practices in company of special interest.

Alfonso Martin Carnicero

Alfonso Martin Carnicero

Phone: +34 941 298 000 (Ext.:81084)

Biosketch

Graduated in Medicine by the University of Salamanca (1999-2005).

Resident of medical oncology at the University Hospital Marqués de Valdecilla of Santander (2006-2010).

Master's degree in support treatment and palliative care in the cancer patient by the University of Salamanca (2008-2009).

Master's degree in clinical and applied research in oncology by the University San Pablo CEU (2014-2015)

Diploma of Advanced Studies (DEA) by the University of Cantabria (2009)

Since 2010, he has been working in the medical oncology department of the Hospital San Pedro of Logroño, focusing his work on digestive tumors, gynecological tumors and melanoma.

Currently undertaking doctoral studies at the University of La Rioja.

Collaborator in several scientific projects of the Biomedical Research Center of La Rioja (CIBIR)

María Díaz de Cerio Flores

María Díaz de Cerio Flores

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 278 770 (Ext.:84866)

Biosketch

María studied Biology and Biochemistry at University of Navarra where she graduated in 2012. Then she studied the Master degree of Virology at Complutense University of Madrid. During this time, she worked at the National Centre of Microbiology, a part of the Carlos III Health Institute, developing her end-of-Master’s project; Human Parechovirus TIII and its implications in pathogenity, supervised by Dr María Cabrerizo. She obtained her Virology Master degree in September 2014.

In 2015 she started her second Master degree in Chemistry and Biotechnology at University of La Rioja (Logroño). In February 2016 she joined Dr Alfredo Martinez´s research group at CIBIR (Centre for Biomedical Research of La Rioja) to conduct her end-of-Master’s project; Characterization of Small Molecules which modulate CIRP expression until September 2016.

Now, she continues in the same research line as a predoctoral researcher.

Francisco José Julián Villaverde

Francisco José Julián Villaverde

Neurology, Hospital San Pedro.

Phone: +34 941 278 855

Judit Narro

Judit Narro

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 278 855 (Ext.:84880)

Biosketch

Judit Narro studied Pathological Anatomy and Cytology at “I.E.S. Montes Obarenes” in Miranda de Ebro, Burgos, where she graduated in 2005. In 2011 she passed the International Academy of Cytology Comprehensive Cytotechnology Examination.

Between 2006 and 2011 she worked at Hospital San Pedro in Logroño, which belongs to the “Servicio Riojano de Salud” in the Pathological Anatomy service, specifically in the cytological screening section. She combined this dedication with work at the Medipat Laboratory of Pathology in Logroño, where she worked as specialist laboratory technologist of Pathology.

From 2011 she works as a specialist technician at the Centro de Investigación Biomédica de La Rioja (CIBIR) in Logroño. She works in the Angiogenesis group, directed by Dr Alfredo Martínez.

She has collaborated in the publication of several scientific articles and has assisted and presented posters in several international Congresses.

Publications

 

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Míriam Bobadilla Muñoz

Míriam Bobadilla Muñoz

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 278 855 (Ext.: 84868)

Biosketch

Miriam Bobadilla Muñoz graduated in Biology and Biochemistry from the University of Navarra in 2007. Later, she obtained a Cellular and Molecular Biology Master's Degree in the same university in 2008. During this time, she studied LMO2 expression and its role as a prognostic marker in leukemia, in Dr. Martinez-Climent´s laboratory.

Doctor in Biochemistry from the University of Navarra (2012). She obtained her phD in the cell therapy laboratory at the Center for Applied Medical Research (CIMA), supervised by Dr. Felipe Prosper and Dra. Ana Pérez-Ruiz. During this time, she studied the satellite cell biology, mainly in degenerative diseases such as Duchenne muscular dystrophy. Also, during those years she worked as an assistant professor in the microbiology department at the University of Navarra.

From 2013 to 2019, she has worked as a postdoctoral researcher in the regenerative medicine area at the Center for Applied Medical Research (CIMA). She focused her studies on cell aging.

Recently, she has incorporated to Dr. Alfredo Martinez laboratory at the Biomedical Research Center of La Rioja (CIBIR).

During these years, she has acquired extensive experience in handling laboratory animals. She has published several research articles in high-impact journals, more than 20 national and international communications. She has also participated in more than 10 national and international research projects, financed by both private and public funds.

Publications

Maria Pilar Martinez Moral

Biosketch

Maria Pilar Martinez Moral graduated in Chemistry in 2009 and obtained her PhD diploma in Analytical Chemistry by the University of La Rioja in 2015.

In April 2015, she started her postdoctoral experience in Dr. Rosato´s research group at the Houston Methodist Hospital Research Institute (Houston, TX, US), where she studied the mechanisms involved in the development of antibiotic resistance in MRSA. In December 2016, she joined Dr. Kannan´s laboratory at the Wadsworth Center (New York Department of Health, Albany, NY, US) as research affiliate. There, she participated in biomonitoring projects, and in the determination of organic contaminant metabolites and oxidative stress biomarkers in biological samples.

In September 2019, she joined the Oncology research group headed by Dr. Alfredo Martinez at the Center for Biomedical Research of La Rioja (CIBIR) after the concession of the “Beca Stop Fuga de Cerebros” contract by the Fundación Rioja Salud in collaboration with Roche Farma, to participate in research projects about the study of biomarkers for the early diagnosis of pancreatic cancer.

Publications

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Pablo Garrido Rodriguez

Biosketch

Pablo Garrido Rodriguez finished his degree in Biology in 2016 at the University of Salamanca. During the last year, he developed his final degree work at the Institute of Functional Biology and Genomics in the group of Dra. Mónica Segurado.

Subsequently, he completed the Master in Biomedical Research at the Faculty of Medicine of the University of Valencia, where he did his end-of-master work at the University Hospital Doctor Peset under the supervision of Doctor José Miguel Nogueira.

In May 2019 he joined the Angiogenesis group of the Oncology Department directed by Dr. Alfredo Martínez of the Biomedical Research Center of La Rioja through an ADER grant to support research financed by the European Social Fund, where he continued with his doctoral thesis.

Collaborators

Universidad de La Rioja:

  • Francisco Corzana López
  • Pedro J. Campos
  • Jesús Manuel Peregrina García

Universidad San Pablo-CEU (Madrid):

  • Ana María Ramos González
  • Beatriz de Pascual Teresa Fernández
  • Claire Coderch Boué

Universidad de Buenos Aires (Argentina):

  • Manuel Rey Funes
  • César Fabián Loidl

Instituto Nacional del Cáncer (NCI) USA:

  • Frank Cuttitta
  • Bradley St Croix

Instituto Cajal, CSIC (Madrid):

  • Ricardo Martínez Murillo
  • Julia Serrano Masa
  • Ana Patricia Fernández

Universidad de Navarra (Pamplona):

  • María Javier Ramírez Gil
  • Francisco Gil Bea

Max Plank Institute (Alemania):

  • Katharina Landfester

Sofia University (Bulgaria):

  • Stanislav Baluschev

Technion Israel Institute of Technology (Israel):

  • Guy Bartal
  • Amir Rosenthal
  • Bergin Gjonaj
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