Proliferation and differentiation in cancer

Team

  • Principal Researcher: Juan Cabello
  • Postdoctoral Researcher: Eva Mª Gómez-Orte
  • Predoctoral Researcher: Angelina Zheleva
  • Laboratory Technician: Begoña Ezcurra

Research

The group is focused on the study of cell differentiation and proliferation. These processes are of crucial importance in embryonic development and tumor progression. During development, cells must be divided many times and at a high rate to generate all the cells that form an adult organism.

Also, the cells must differentiate (specialize) to form the various tissues that form an organism: neurons, muscles, skin, etc. However, mutations in genes that regulate these processes derive in the problems of differentiation that characterize the tumor cells.

The group mainly uses the model organism Caenorhabditis elegans, which is a nematode (worm) widely used in research for its ease handling and its degree of homology with humans (60%).

Research Lines

In general, this search intends:

  1. Study the native function of genes that regulate cell division / differentiation during development and how the mutation of those genes alter molecular processes.
  2. Understand the pathological consequences of mutation of these genes in certain tumors (such as those that correlate with mutations in the Integrator Complex).
  3. To unravel the mechanism of tumor transformation to expose possible markers that serve to improve the diagnosis or serve as therapeutic targets.

General objectives:

  1. Study of the processes related to RNA metabolism (processing, transport, etc.) in cell differentiation during development. Analysis of its implications in tumor processes. Study of its regulation and search for other elements that control its activity to, in this way propose possible therapeutic targets.
  2. Integrator Complex Study: A group of proteins involved in the processing of small nuclear RNAs (snRNAs). Mutations in the Integrator Complex correlate with various tumors. We intend to understand the function of its components in the regulation of genetic transcription.
  3. Characterization of the RNA transporters from the nucleus to the cytoplasm. Study of its function and consequences of its deregulation.

Other lines

Nutrition and genetics: study of how the individual's genetic condition affects his nutrition and vice versa, how individual nutrition affects his gene expression.

Principal Researcher

Juan Cabello

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: + 34 941 278 873

Biosketch

JC studied Biology at the University of Salamanca (Spain). In 1999 obtained his PhD. in the Department of Microbiology and Genetics at the University of Salamanca (Spain).

Between 2000 and 2006, he was a Postdoctoral fellow in the laboratory of Prof. Ralf Schnabel at the Institute of Genetics of the Technical University of Braunschweig (Germany).

From 2006 until mid 2009 he worked in Dr. Sergio Moreno’s group at the Cancer Research Center (CSIC (Higher Council for Scientific Research) / University of Salamanca) (Spain).

He is currently Group Leader in the Oncology Area of the CIBIR (Center for Biomedical Research of La Rioja).

Work Team

Eva Mª Gómez-Orte

Eva Mª Gómez-Orte

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 278 855 (Ext.:84868)

Biosketch

Dr Eva Gomez Orte obtained her degree in Biology from the University of Navarra and she got her Master degree in Biotechnology from University of Barcelona. She obtained her Ph.D in Biology from the University of Barcelona. During her thesis she worked in the characterization of mobile elements.

She pursued postdoctoral training at: Department of Pharmaceutics and Pharmaceutical Technology in Trinity College Dublin, Ireland, 2002-2003; Department of Genetics, Smurfit Institute, Trinity College of Dublin, Ireland 2003-2007 and she participated in the European project: Virus-Induced Gene Silencing. Eva returned to Spain in 2007 as I3P researcher of the Institute of Evolutionary Biology of Barcelona, CSIC-UPF, to work in the project: Silencing the Silencing machinery.

In 2009 Eva Gomez Orte joined the group of Proliferation and Differentiation at the Centre for Biomedical Research of La Rioja (CIBIR). She is working as senior Postdoctoral researcher and she is involved in the design and execution of the research projects, training and co-direction of PhD students. In 2015 she received the Assistant teacher doctor accreditation by The National Agency for Quality Assessment and Accreditation of Spain (ANECA).

Eva Gomez Orte has done short term stays at different Institutes: Institute of Biotechnology, University of Helsinki, Finland, 2001; Department of Plant Science, Wageningen, The Netherlands, 2004; Biotechnology Center, Godollo, Hungary, 2005; Martin Chalfie laboratory, Columbia University, New York, 2014. She has been awarded with national and international fellowship: T-DOC, CIRIT-Generalitat de Catalunya (2000-2001), EMBO fellowship (2001), CSIC/I3P-doc program, Spanish National Research Council Fellowship (2007-2009).

Angelina Zheleva

Angelina Zheleva

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 627 225 969

Biosketch

Angelina Zheleva obtained her bachelor’s degree in Bioinformatics from the Plovdiv University “Paisii Hilendarski“, Plovdiv, Bulgaria in 2010. During this period she worked in project “Identification of cis- regulatory promoter elements specified for different Reactive oxygen species (ROS) in Arabidopsis thaliana“ at Plovdiv University, Faculty of Biology, led by Dr. Tsanko Getchev.

She continued her studies and obtained a Master in Bioinformaics from Plovdiv University in 2013. During her master’s internship she characterized a TREX-2 complex in C. elegans at the Prof. Andres Aguilera´s laboratory, Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) Sevile, Spain.

Currently, Angelina is working on her Biomedicine PhD project focused on pharyngel morhogenesis in C.elegans, which she started at the CIBIR in 2013 under the direction of Dr. Juan Cabello.

Begoña Ezcurra

Begoña Ezcurra

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 278 770 (Ext.:84880)

Biosketch

She studied Higher Laboratory Technician (Clinical Diagnosis) at IES Valle del Cidacos (Calahorra, La Rioja) ending in June 2002

From 2005 to 2007 she worked at the Center for Advanced Studies in Blanes (CSIC) as Research Support Technician.

Between 2007 and 2010 she was working in several hospitals as Clinical Diagnostic Technician.

In February 2010 she began working at CIBIR in Dr. Juan Cabello’s lab of Cell Proliferation and Differentiation where she continues today.

Begoña Sacristan Terroba

Begoña Sacristan Terroba

Hospital San Pedro.

Victor Escrich

Victor Escrich

Hospital San Pedro.

Collaborators

Instituto de Medicina Clínica Universidad Oslo Noruega:

Institute of Genetics, TU Braunschweig, Germany:

Idibell, Barcelona, Spain:

Instituto de Biomedicina de Sevilla - IBIS, Sevilla, Spain:

© 2021 Rioja Salud - C/ Piqueras, 98 – 3ª Planta · 26006 · Logroño · La Rioja · Telf.: 941 278 855 · Fax: 941 278 887