Inflammation and Ageing Unit

Team

  • Principal Researcher: José Antonio Oteo Revuelta
  • Researcher in charge of the Laboratory: José Ramón Blanco-Ramos
  • Postdoctoral Researcher: Laura Pérez-Martínez
  • Laboratory Technician: Lourdes Romero-Barruete
  • Collaborators:
    • María Gómez-Eguilaz
    • Beatriz Fernández-Vallejo

Research

In recent decades, and as a consequence of the effectiveness of antiretroviral therapy and its accessibility, life expectancy of HIV-infected patients has increased considerably. For this reason, HIV infection is considered now a chronic disease. However, these patients show many of the clinical features observed in elderly patients at a younger age as a consequence of its accelerated and accentuated ageing. This clinical picture may be complicated by other risk factors such as oncogenic viruses or substance abuse. In addition, there is also a low-grade inflammation that exacerbates the prognosis of these patients and their comorbidities, what has been called "inflammaging".

This line, a priority at national and European level, will allow us to improve the knowledge of the mechanisms involved in the development of ageing and its complications. This information will help us to improve the earlier diagnosis of this process (i.e. search for biomarkers of ageing). The results of this research will benefit not only to HIV-infected patients, but also the general population. Indeed, this line opens the way to the use of new indications with already commercialized drugs. Finally, ageing could be considered as another one chronic disease whose development could be slow or even turned back. This line, which addresses the different biological mechanisms of ageing, has a clearly translational and clinical research profile.

Our research line is also focused on other research activities:

  • Study of the preventive and therapeutic effects of CCR5 antagonist on multiple human diseases.
  • Study of other inflammatory processes: liver damage (i.e. non-alcoholic fatty liver).
  • Evaluation of the human health properties of the probiotics.
  • Projects applied to health technology.

Principal Researcher

José Antonio Oteo Revuelta

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 278 770 (Ext.: 89871)

Biosketch

José Antonio Oteo (MD, PhD in Medicine and Surgery, University of Navarra, 1990) is a Specialist in Internal Medicine (MIR Program carried out at Hospital Virgen del Camino, Pamplona, Spain). He has been the Head of the Internal Medicine Service of the Hospital of La Rioja and Hospital San Millán-San Pedro- in La Rioja. He is currently the Head of the Infectious Diseases Department (formerly known as Clinical Management Area) at the Hospital San Pedro, La Rioja (Spain). He is also the Head of the Infectious Diseases Department of the Center for Biomedical Research of La Rioja (CIBIR), which includes three units: the Laboratory of Special Pathogens (Center of Rickettsiosis and Arthropod-Borne Diseases); the Unit of Infectious Diseases, Microbiota and Metabolism and the Unit of Infections, Inflammation and Aging. In this research center, he manages and supervises a laboratory equipped with the latest technologies in molecular and cellular biology and a biosafety level-3 facility for handling dangerous and fastidious microorganisms.

In the field of arthropod vectors research, the group that he leads has been pioneer in the description of new tick-borne diseases, such as DEBONEL, and/or non-previously described illnesses in our environment. They have also significantly contributed to the isolation and involvement of new microorganisms in human pathology, such as Rickettsia monacensis or the new Rickettsia rioja. Besides, other Rickettsia spp., such as Rickettsia vinior Rickettsia colombianensi (to date no associated with human diseases), have been characterized. The biggest series of patients with Lyme disease in Spain and studies in the arthropod vectors have been also reported by this group. The first cases of human anaplasmosis in the South of Europe, the first cases of Rickettsia sibirica mongolitimonae infection, the first implication of Rickettsia massiliae as human pathogen in America, the first case of neurotoxic paralysis after tick-bite, the circulation of ´Ca. Neoehrlichia mikurensis´ in Spain, and the description of tularemia after tick-bite are among other relevant achievements. The first cluster of cases of human Rickettsia felis infection in Spain and the first infestation with trombiculid mites (Neotrombicula inopinata) as causative agents of seasonal dermatitis in the world have been also described by this group. It is also worth mentioning the first description of Crimean-CongoHemorrhagic Fever in ticks from Occidental Europe and in ticks removed from migratory birds in the North of Africa. These findings were essential for a rapid health response to the first two autochthonous cases detected in Spain in August-September 2016.

In addition, this group has managed more than 1 million euros in research funding in recent years.

Concerning his activity in the Unit of Infectious Diseases, Microbiota and Metabolism he has focused his interest on the study of gut microbiota composition in different infectious and relevant pathologies through next-generation technologies. He has also been involved in the analyses of data obtained by transcriptomics and lipidomics in order to find out early biomarkers of these pathologies. In addition, he has also participated in several national and international projects in this field and has published several studies in high impact journals.

His experience in lecturing includes the post-graduate training of resident doctors, his involvement in several PhD courses carried out in different Universities as well as his contributions as Invited Professor in several courses in the field of Medicine and Nursing. He is the Professor in charge of the practices of medical students in the Hospital San Pedro and the person in charge of lecturing Physiology-I in the Degree of Nursing of the University of La Rioja. He has supervised several Doctoral Theses, Diploma of Advanced Studies (DEAs), Master Projects and Final-Degree Projects. He is accredited by the ANECA as Profesor Titular de Universidad in the area of Medicine.

As result of his research activity, he has published more than 350 publications in scientific journals, books and monographs. During his professional practice he has participated, as principal investigator (PI) in most cases, in numerous competitive research projects.

He currently leads a clinical group associated with the Spanish Infectious Pathology Research Network (REIPI); his team is also part of the Spanish AIDS Research Network (RIS); he is an expert of the VectorNet network, which depends on the ECDCs, and is member of the European Network for Neglected Vectors and Vector-Borne Infections (EurNegVec Cost Action). Recently, his team has joined the Network of Biological Alert Laboratories (RE-LAB), set up to respond to threats by dangerous biological agents. His contributions frequently appear in official programs of national and international congresses of relevance in the field of infectious diseases. He has been the Chairman of the Scientific Committee of the Congress of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and President of several National and International Study Groups, such as the Special Pathogens group of the SEIMC and the Coxiella, Anaplasma, Rickettsia and Bartonella group from the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). He is part of the editorial committee of several scientific journals and acts as evaluator of the National Agency for Evaluation and Prospecting (ANEP) and of different agencies from other countries such as Portugal, Norway and Argentina. He has also the honor of having received numerous scientific and social awards.

Publications

 

ncbi

 

Work Team

José Ramón Blanco

José-Ramón Blanco-Ramos

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 298 993

Biosketch

José-Ramón Blanco, MD, PhD received his medical degree at the University of Zaragoza, after that he did his specialty in Internal Medicine. Since 2002 he joined to the Department of Infectious Diseases at Hospital San Pedro in Logroño, where he is a Consultant.

He is the responsible of the HIV, Inflammation and Ageing Unit. His major research interest is focused on ageing as a consequence of HIV infection. He is also interested in the inflammatory mechanism in animal models of liver injury (i.e. non-alcoholic fatty liver disease) and ageing, with emphasis on the role of CCR5 antagonist.

During the last 15 years he has been the PI or Co-Investigator of several research projects related to HIV infection and liver damage. He has produced more than 100 Peer-Reviewed publications in national and international journals. He is Member of the Spanish HIV Cohort, national reviewer of research projects, and member of different national and international scientific societies.

Publications

 

ncbi

 

Laura Pérez-Martínez

Laura Pérez-Martínez, PH.D.

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 278 870

Biosketch

Laura Pérez-Martínez, graduated in Biology (Fundamental and Health Specialty) at the University of Navarra. She obtained her Doctorate at the University of La Rioja. Since 2005, she joined to the Research Laboratory of the Department of Infectious Diseases at the Hospital San Pedro.

Now, she is working on the HIV, Inflammation and Ageing Unit. Her main research is focused on ageing biomarkers and inflammatory pathways in animal models (i.e. non-alcoholic fatty liver disease and ageing models). She has worked on the human papilomavirus associated with HIV infection.

She is currently member of the research team of several HIV projects and has participated in more than 10 HIV-related clinical trials.

She has published more than 20 Peer-Reviewed publications in national and international journals. She is member of the Spanish HIV Cohort, and member of different national scientific societies.

Publications

 

ncbi

 

Lourdes Romero-Barruete

Lourdes Romero Barruete

Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Phone: +34 941 278 870

Biosketch

Lourdes Romero Barruete is a laboratory technician. Since 1989, she has been working in different laboratories, both in clinical diagnosis and specialized research units. During that time she has specialized in multiple laboratory procedures focused on molecular biology, cancer, gene therapy, genetic engineering, proteins and diagnosis. Now, she is working on the HIV, Inflammation and Ageing Unit. She has published more than 20 Peer-Reviewed publications in national and international journals.

In her C.V. Include research projects, publications, and research courses.

Publications

 

ncbi

 

María Gómez-Eguilaz

María Gómez-Eguilaz

Phone: +34 941 278 855

Biosketch

María Gómez-Eguilaz, graduated in Medicine at the University of Navarra. She did her specialty in Neurology and after that she obtained her Doctorate at the University of Zaragoza. Since 2013 she joined to the Neurology Service at Hospital San Pedro, where she is a Consultant. Her major research interest is focused on epilepsy and the role of the probiotics in this disease. She has been the PI or Co-Investigator of several research projects related to neurological disorders. She is member of different national and international scientific societies.

Beatriz Fernández-Vallejo

Beatriz Fernández-Vallejo

Phone: +34 941 278 855

Biosketch

Beatriz Fernández-Vallejo did her specialty in Family Practice and Pediatry. Since 2008 she joined to the Pediatric Service at Hospital San Pedro, where she is a Consultant. Her major research interest is focused on metabolic syndrome and NAFLD in child and adolescent. She has been the PI or Co-Investigator of several research projects related to pediatric diseases. She is member of different national scientific societies.

© 2020 Rioja Salud - C/ Piqueras, 98 – 3ª Planta · 26006 · Logroño · La Rioja · Telf.: 941 278 855 · Fax: 941 278 887